World's unhappiest regions concentrate in Sub-Saharan Africa & conflict zones. Afghanistan maintains consistent bottom ranking 2021-2024. South Sudan, Zimbabwe, Rwanda maintain bottom 10 regulars. Regional average of 4.0-4.5 on 10-point scale. GDP per capita of $500-$2,000 creates extreme poverty. Unemployment of 20-50% creates joblessness crisis. Life expectancy of 45-60 years reveals health catastrophe. Conflict & institutional collapse create despair. Gender inequality & social discrimination compound suffering.